Mast Cells and Angiogenesis in Oral Epithelial Dysplastic Lesions and Oral Squamous Cell Carcinoma
نویسنده
چکیده
Background: The progression of oral epithelial dysplastic lesions into oral squamous cell carcinoma is characterized by an ‘angiogenic switch’ which is characterized by an increase in neo-vascularization in the subepithelial lamina propria which can be considered an indicator of malignant transformation. Mast cells are a rich source of various angiogenic factors. Moreover mast cells secrete various proteolytic enzymes which degrade the extracellular matrix and create space for the developing blood vessels. Aims: This study was undertaken to determine the relationship between mast cell density and microvessel density in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma and to find out whether any correlation exists between these two parameters. Material and Methods: This retrospective study was performed using formalin fixed, paraffin embedded tissues of previously diagnosed cases of oral epithelial dysplasia and oral squamous cell carcinoma. Mast cells were stained using toluidine blue, whereas in the capillaries, immunohistochemical staining technique was performed using mouse monoclonal antibody against CD34. Results: Mast cell density and microvessel density were higher in oral epithelial dysplasia and in oral squamous cell carcinoma compared to the normal mucosa. However, statistically significant positive correlation was noted only in oral epithelial dysplasia Conclusion: The above results probably indicate a role of mast cells in ‘angiogenic switch’. These angiogenic factors secreted by mast cells promote angiogenesis either directly by stimulating the migration and/or proliferation of mast cells or indirectly through degradation of extracellular matrix. Targeting the mast cells may contribute in preventing the progression of the lesion.
منابع مشابه
Angiogenesis and Tumor-Associated Macrophages in Different Grades of Oral Squamous Cell Carcinoma, Verrucous Carcinoma and Epithelial Dysplasia via Immunohistochemical Assessment of Expression of CD34 and CD68 Markers
Background:Squamous cell carcinoma (SCC) is the most common malignancy of the oral cavity, which is highly invasive. Verrucous carcinoma (VC) is the low-grade form of SCC. Epithelial dysplasia (ED) also has a malignant potential. This immunohistochemical (IHC) study aimed to assess angiogenesis and the presence of tumor-associated macrophages (TAMs) in SCC, VC and ED to determi...
متن کاملMast cell density and angiogenesis in oral dysplastic epithelium and low- and high-grade oral squamous cell carcinoma.
OBJECTIVE Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors and SCC accounts for approximately 94% of all oral malignancies. The risk of malignant transformation in dysplastic lesions is greater than that of normal oral mucosa. The definite roles of mast cells and angiogenesis in OSCC have been under debate. The aim of this study was to compare mast cell count (M...
متن کاملA comparative study on the mast cells count in oral squamous cell carcinoma and normal oral mucosa
Introduction: Oral squamous cell carcinoma (OSCC) is one of the 10 most common malignant tumors and SCC accounts 94% of all oral malignancies. Mast cells are regarded as complex and multifunctional cells, playing a significant role in immunopathology . The aim of this study is to evaluate the number of mast cells in tissue sections of oral squamous cell carcinoma (OSCC) in comparison with norma...
متن کاملبررسی مقایسه ای تعداد ماست سل ها در کارسینوم سلول سنگفرشی حفره دهان و پوست ناحیه سر و گردن
Background and purpose: Mast cells as the multi-functional and complex cells play a key role in tumor progression. Due to the higher malignant potential of Oral Squamous cell carcinoma (OSCC) compared with cutaneous squamous cell carcinoma (cSCC), the purpose of this study was to compare the mast cells count in squamous cell carcinoma of the skin and oral cavity and evaluate their correlation w...
متن کاملبررسی تراکم ماستسل در کارسینوم سلول سنگفرشی و مخاط دیسپلاستیک حنجره
Background and Objective: The role of mast cells in carcinogenesis is improved in many malignant neoplasms but there are scanty literature which show the role of these cells in pathogenesis of progression of dysplastic lesion to invasive squamous cell carcinoma (SCC). The aim of this study was comparison of mast cell density between squamous cell carcinoma and dysplastic laryngeal mucosa to inv...
متن کامل